Research group of Dr. R. Gerlach

Modulation of Salmonella virulence by host signals

Salmonellosis is one of the most common bacterial infectious diseases worldwide and in Germany. Our group investigates molecular mechanisms underlying the pathogenicity of Salmonella enterica. In particular, bacterial secretion systems are in focus. Secretion systems play a crucial role in pathogenicity, as Salmonella uses these structures and their substrates to interact with host cells and other bacteria. Furthermore, we investigate the influence of host-specific environmental factors on the regulation and function of Salmonella virulence factors. Environmental signals, such as decreased oxygen, play a crucial role in host cell recognition as well as successful adaptation of bacteria to different habitats within the host.

Microbiome analyses

For successful colonization, Salmonella and other pathogens must also overcome the barrier function established by the host microbiota. Therefore, another focus of our group is the analysis of the microbiota composition of humans and using animal models in health and disease. For cooperation partners from applied clinical and basic research we provide amplicon-based (16S rDNA) analysis of microbial community structures using an Illumina MiSeq system and state-of-the-art bioinformatics tools.