Prof. Dr. med. Jochen Mattner

 Professur für Molekulare Mikrobiologie und Infektionsimmunologie

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Curriculum vitae

Education, Training and Academic Positions

1995-2001 Studies of medicine at the Friedrich-Alexander-University Erlangen-Nürnberg
1998-2002   Research doctorate (experimental doctoral thesis), Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen-Nürnberg
2002          "Summa cum laude" doctoral degree (Dr. med., M.D.) of the Friedrich-Alexander-University Erlangen for the thesis "Regulation of inducible nitric  oxide synthase by Type I Interferon"
2002-2003   Resident medical doctor and postdoctoral research fellow at the Institute of Clinical Microbiology, Immunology and Hygiene, University      of Erlangen-Nürnberg 
2003-2005   Postdoctoral fellow, University of Chicago, Department of Pathology
2006-2007   Research Assistant Professor, Department of Pathology, University of Chicago
2008-2010   Assistant Professor, Cincinnati Children’s Medical Center, Division of Immunobiology
2010           Professor of Molecular Microbiology and Infection Immunology, Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen-Nürnberg

Prices / Awards:

1994 Scholarship for highly talented students awarded by the Bavarian Government
2002 Price for graduation by the University of Erlangen - best thesis in 2002
2005 CRI grant Award
2005 Keystone travel grant Award
2006 ECIS travel grant Award
2006 Fritz - und - Ursula - Melchers price at the 1st combined meeting of the European Societies for Immunology, Paris, France
2007 AAI young faculty award

Memberships in Scientific Societies:

1999 German Society for Immunology
2000 European Macrophage and Dendritic Cell Society

Memberships to Editorial Boards of International Journals:

World Journal of Hepatology

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Publikationen

• Mattner J., Schindler H., Diefenbach A., Röllinghoff M., Gresser I., and Bogdan, C. Regulation of type 2 nitric oxide synthase by type I interferon in macrophages infected with Leishmania major. Eur J. Immunol. 2000. 30: 2257-2267.
• Bogdan C. Mattner J., and Schleicher U. The role of type I interferons in non-viral infections. Immunological Reviews. 2004. 202: 33-48.
• Mattner J., Wandersee-Steinhauser A., Pahl A., Rollinghoff M., Majeau G.R., Hochman P.S., and Bogdan C. Protection against progressive leishmaniasis by IFN-beta. J. Immunol. 2004. 172: 7574-7582.
• Ritter U., Mattner J., Rocha J.S., Bogdan C., and Korner H. The control of Leishmania major by TNF in vivo is dependent on the parasite strain. Microbes Infect. 2004. 6: 559-565.
• Schleicher U., Mattner J., Blos M., Schindler H., Rollinghoff M., Karaghiosoff M., Muller M., Werner-Felmayer G., and Bogdan C. Control of Leishmania major in the absence of Tyk2 kinase. Eur. J.Immunol. 2004. 34: 519-529.
• Goff R., Gao Y., Mattner J., Zhou D., Ning Y., Cantu III C., Teyton L., Bendelac A., and Savage P.B. Synthesis of alpha-Galactosylceramides and their effects ob cytokine release by natural killer T cells. JACS. 2004. 126: 13602-13603.
• Zhou D., Mattner J., Cantu III C., Schrantz N., Ning Y., Gao Y., Sagiv Y., Hudspeth K., Wu Y., Teneberg S., Wang D., Proia R., Levery S.B., Savage P.B., Teyton L., and Bendelac A. An endogenouslysosomal glycoshingolipid recognized by mouse and human NKT cells, Science. 2004. 306: 1786-1789.
• Mattner J., DeBord K.L., Goff R.D., Cantu III C., Zhou D., Saint-Mezard P., Wang V., Gao Y., Yin N., Hoebe K., Schneewind O., Ismail N., Walker D., Beutler B., Teyton L., Savage P.B., and Bendelac A. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 2005. 434: 525-529. Article has been cited 354 times in Scopus
• Zajonic D.M., Cantu III C., Mattner J., Zhou D., Savage P.B., Bendelac A., Wilson I.A., and Teyton L. Structure and function of a potent a-galactosylceramide agonist for the semi-invariant NKT cell receptor. Nature Immunology. 2005. 6: 810-818
• Mattner J., Donhauser N., Werner - Felmayer G., and Bogdan C. NKT cells mediate organ-specific resistance against Leishmania major infection. Microbes Infect. 2006. 8: 354-62
• Sagiv Y. Hudspeth H., Mattner J., Schrantz N., Stern R., Zhou D., Savage P.B., Teyton L., and Bendelac A. Cutting Edge: Impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein. J. Immunol. 2006. 177: 26-30
• Liu Y., Goff R.D., Zhou D., Mattner J., Sullivan B.A., Khurana A., Cantu C. 3rd, Ravkov E.V., Ibegbu C.C., Altman J.D., Teyton L., Bendelac A., and Savage P.B. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. J Immunol Methods. 2006. 312: 34-39
• Long X., Deng S., Mattner J., Zang Z., Zhou D., McNary N., Goff R.D., Teyton L., Bendelac A., and Savage P.B. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Nat.Chem.Biol. 2007. 3: 559-564.
• Rocha F.J., Schleicher U., Mattner J., Alber G., and Bogdan C. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect. Immun. 2007. 75: 3823-3833
• Pedra, J.H., Mattner J., Tao J., Kerfoot S.M., Davis R.J., Flavell R.A., Askenase P.W., Yin Z., and Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infect Immun. 2008. 76: 308-316.
• Liu Y., Deng S., Bai L., Freigang S., Mattner J., Teyton L., Bendelac A., and Savage P.B. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties. Bioorg Med Chem Lett. 2008. 18: 3052-3055.
• Mattner J., Savage P.B., Leung P., Oertelt S.S., Wang V., Trivedi O., Scanlon S.T., Pendem K., Teyton L., Hart J., Ridgway W.M., Wicker L.S., Gershwin M.E., and Bendelac A. Liver autoimmunity triggered by NKT cells. Cell Host & Microbe. 2008. 3: 304-315.
• Vas, J., Mattner J., Richardson S., Ndonye R., Gaughan J.P., Howell A., and Monestier M. Regulatory roles for NKT cell ligands in environmentally-induced autoimmunity. J. Immunol. 2008. 3: 304-315
• Yin, N., Long, X., Goff, R., Zhou, D., Cantu III, C., Mattner J., Saint-Mezard, P., Teyton, L., Bendelac, A., and Savage, P.B. Alpha Anomers of iGb3 and Gb3 Stimulate Cytokine Production by Natural Killer T Cells. ACS Chem. Biol. 2009. 20: 199-208. Mohammed J., and Mattner J. Autoimmune disease triggered by infection with alphaproteobacteria. Expert Rev. Clin. Immunol. 2009. 5: 369-379