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Prof. Dr. med. Roland Lang

Prof. Dr. med. Roland Lang

Stellvertretender Institutsdirektor

Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene
Wasserturmstraße 3/5
91054 Erlangen


Lebenslauf, Veröffentlichungen und Auszeichnungen

Professur für Angeborene Immunität und Pathogenerkennung



  • Stebner A, Ensser, A., Geissdoerfer, W., Bozhkov, Y., Lang, R. 2020. Molecular diagnosis of polymicrobial brain abscesses with 16S rDNA-based next generation sequencing. Clinical Microbiology and Infection accepted
  • Schick J, Schafer J, Alexander C, Dichtl S, Murray PJ, Christensen D, Sorg U, Pfeffer K, Schleicher U, Lang R. 2020. Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity. J Immunol 205: 323-8
  • Huber A, Killy B, Grummel N, Bodendorfer B, Paul S, Wiesmann V, Naschberger E, Zimmer J, Wirtz S, Schleicher U, Vera J, Ekici AB, Dalpke A, Lang R. 2020. Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-gamma towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1. J Immunol 205: 1580-92
  • Andreev D, Liu M, Weidner D, Kachler K, Faas M, Gruneboom A, Schlotzer-Schrehardt U, Munoz LE, Steffen U, Grotsch B, Killy B, Kronke G, Luebke AM, Niemeier A, Wehrhan F, Lang R, Schett G, Bozec A. 2020. Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. J Clin Invest
  • Weerasekera D, Fastner T, Lang R, Burkovski A, Ott L. 2019. Of mice and men: Interaction of Corynebacterium diphtheriae strains with murine and human phagocytes. Virulence 10: 414-28
  • Pulido R, Lang R. 2019. Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function. Int J Mol Sci 20
  • Moller J, Kraner M, Sonnewald U, Sangal V, Tittlbach H, Winkler J, Winkler TH, Melnikov V, Lang R, Sing A, Mattos-Guaraldi AL, Burkovski A. 2019. Proteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae. Vaccine 37: 3061-70
  • Lepenies B, Lang R. 2019. Editorial: Lectins and Their Ligands in Shaping Immune Responses. Front Immunol 10: 2379
  • Lang R, Raffi FAM. 2019. Dual-Specificity Phosphatases in Immunity and Infection: An Update. Int J Mol Sci 20
  • Kohl L, Hayek I, Daniel C, Schulze-Luhrmann J, Bodendorfer B, Luhrmann A, Lang R. 2019. MyD88 Is Required for Efficient Control of Coxiella burnetii Infection and Dissemination. Front Immunol 10: 165
  • Hayek I, Fischer F, Schulze-Luehrmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Luhrmann A. 2019. Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages. Cell Rep 26: 3502-10 e6
  • Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Hartlova A, Uebel S, Bosmann M, Hofmann J, Buttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. 2019. Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling. Mol Cell Proteomics 18: 669-85
  • Spitzer P, Lang R, Oberstein TJ, Lewczuk P, Ermann N, Huttner HB, Masouris I, Kornhuber J, Kodel U, Maler JM. 2018. A Specific Reduction in Abeta1-42 vs. a Universal Loss of Abeta Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis. Front Aging Neurosci 10: 152
  • Patzelt T, Keppler SJ, Gorka O, Thoene S, Wartewig T, Reth M, Forster I, Lang R, Buchner M, Ruland J. 2018. Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells. Proc Natl Acad Sci U S A 115: 3120-5
  • Benard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D. 2018. B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis. Am J Respir Crit Care Med 197: 801-13
  • Zega K, Jovanovic VM, Vitic Z, Niedzielska M, Knaapi L, Jukic MM, Partanen J, Friedel RF, Lang R, Brodski C. 2017. Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci 10: 372
  • Winterholler M, Coras R, Geissdorfer W, Rammensee R, Golitz P, Bogdan C, Lang R. 2017. Fatal Mycotic Aneurysm of the Basilar Artery Caused by Aspergillus fumigatus in a Patient with Pituitary Adenoma and Meningitis. Front Med (Lausanne) 4: 113
  • Velasquez LN, Milillo MA, Delpino MV, Trotta A, Fernandez P, Pozner RG, Lang R, Balboa L, Giambartolomei GH, Barrionuevo P. 2017. Brucella abortus down-regulates MHC class II by the IL-6-dependent inhibition of CIITA through the downmodulation of IFN regulatory factor-1 (IRF-1). J Leukoc Biol 101: 759-73
  • Tima HG, Al Dulayymi JR, Denis O, Lehebel P, Baols KS, Mohammed MO, L'Homme L, Sahb MM, Potemberg G, Legrand S, Lang R, Beyaert R, Piette J, Baird MS, Huygen K, Romano M. 2017. Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis. J Innate Immun 9: 162-80
  • Steininger PA, Bobinger T, Dietrich W, Lee DH, Knott M, Bogdan C, Korn K, Lang R. 2017. Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention. Open Forum Infect Dis 4: ofx204
  • Schmok E, Abad Dar M, Behrends J, Erdmann H, Ruckerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Holscher C. 2017. Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis. Front Immunol 8: 1537
  • Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, Kirschning C, Burkovski A, Lang R. 2017. Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids. Infect Immun 85
  • Rath T, Atreya R, Geissdorfer W, Lang R, Nagel A, Neurath MF. 2017. A Severe Case of Tuberculosis Radiologically and Endoscopically Mimicking Colorectal Cancer with Peritoneal Carcinomatosis. Case Rep Gastrointest Med 2017: 6206951
  • Patin EC, Geffken AC, Willcocks S, Leschczyk C, Haas A, Nimmerjahn F, Lang R, Ward TH, Schaible UE. 2017. Trehalose dimycolate interferes with FcgammaR-mediated phagosome maturation through Mincle, SHP-1 and FcgammaRIIB signalling. PLoS One 12: e0174973
  • Ott L, Hacker E, Kunert T, Karrington I, Etschel P, Lang R, Wiesmann V, Wittenberg T, Singh A, Varela C, Bhatt A, Sangal V, Burkovski A. 2017. Analysis of Corynebacterium diphtheriae macrophage interaction: Dispensability of corynomycolic acids for inhibition of phagolysosome maturation and identification of a new gene involved in synthesis of the corynomycolic acid layer. PLoS One 12: e0180105
  • Ostrop J, Lang R. 2017. Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors. J Immunol 198: 1403-14
  • Lang R, Schick J. 2017. Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage. Front Immunol 8: 1864
  • Lang R, Mattner J. 2017. The role of lipids in host microbe interactions. Front Biosci (Landmark Ed) 22: 1581-98
  • Kao D, Lux A, Schaffert A, Lang R, Altmann F, Nimmerjahn F. 2017. IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice. Eur J Immunol 47: 2070-9
  • Jurkin J, Krump C, Koffel R, Fieber C, Schuster C, Brunner PM, Borek I, Eisenwort G, Lim C, Mages J, Lang R, Bauer W, Mechtcheriakova D, Meshcheryakova A, Elbe-Burger A, Stingl G, Strobl H. 2017. Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation. J Allergy Clin Immunol 139: 1873-84 e10
  • Spitzer P, Condic M, Herrmann M, Oberstein TJ, Scharin-Mehlmann M, Gilbert DF, Friedrich O, Gromer T, Kornhuber J, Lang R, Maler JM. 2016. Amyloidogenic amyloid-beta-peptide variants induce microbial agglutination and exert antimicrobial activity. Sci Rep 6: 32228
  • Patin EC, Willcocks S, Orr S, Ward TH, Lang R, Schaible UE. 2016. Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immun 22: 181-5
  • Patin EC, Jones AV, Thompson A, Clement M, Liao CT, Griffiths JS, Wallace LE, Bryant CE, Lang R, Rosenstiel P, Humphreys IR, Taylor PR, Jones GW, Orr SJ. 2016. IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-beta Production Inhibits Fungal Clearance. J Immunol 197: 208-21
  • Maor-Nof M, Romi E, Shalom HS, Ulisse V, Raanan C, Nof A, Leshkowitz D, Lang R, Yaron A. 2016. Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors. Neuron 92: 991-1006
  • Hupfer T, Schick J, Jozefowski K, Voehringer D, Ostrop J, Lang R. 2016. Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4. Front Immunol 7: 423
  • Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, Foged C, Lang R. 2016. Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo. Innate Immun 22: 405-18
  • Wenzel J, Ouderkirk JL, Krendel M, Lang R. 2015. Class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release, and antigen presentation via MHC class II. Eur J Immunol 45: 225-37
  • Siegert I, Schodel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J. 2015. Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1alpha upon LPS Activation in the Presence of Ample Oxygen. Cell Rep 13: 2048-55
  • Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B. 2015. The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response. Plos One 10
  • Ostrop J, Jozefowski K, Zimmermann S, Hofmann K, Strasser E, Lepenies B, Lang R. 2015. Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB. J Immunol 195: 2417-28
  • Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R. 2015. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol 195: 1753-62
  • Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwalder M, Knobeloch KP, Prinz M. 2015. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. EMBO J Schoenen
  • H, Huber A, Sonda N, Zimmermann S, Jantsch J, Lepenies B, Bronte V, Lang R. 2014. Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPbeta and HIF1alpha. J Immunol 193: 3664-75
  • Niedzielska M, Bodendorfer B, Munch S, Eichner A, Derigs M, da Costa O, Schweizer A, Neff F, Nitschke L, Sparwasser T, Keyse SM, Lang R. 2014. Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production. J Biol Chem 289: 2112-26
  • Goktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR. 2014. IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells. Cell Rep 7: 1914-25
  • Globisch T, Steiner N, Fulle L, Lukacs-Kornek V, Degrandi D, Dresing P, Alferink J, Lang R, Pfeffer K, Beyer M, Weighardt H, Kurts C, Ulas T, Schultze JL, Forster I. 2014. Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. Eur J Immunol 44: 500-10
  • Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hucking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Volkers M. 2014. IL-1alpha reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol 50: 1096-106
  • Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR. 2013. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152: 25-38
  • Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T. 2013. Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. PLoS Pathog 9: e1003648
  • Held C, Wenzel J, Wiesmann V, Palmisano R, Lang R, Wittenberg T. 2013. Enhancing automated micrograph-based evaluation of LPS-stimulated macrophage spreading. Cytometry A 83: 409-18
  • Heitmann L, Schoenen H, Ehlers S, Lang R, Holscher C. 2013. Mincle is not essential for controlling Mycobacterium tuberculosis infection. Immunobiology 218: 506-16
  • Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger EM, da Costa CP, Lang R. 2013. The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling. Plos One 8
  • Specht S, Taylor MD, Hoeve MA, Allen JE, Lang R, Hoerauf A. 2012. Over expression of IL-10 by macrophages overcomes resistance to murine filariasis. Exp Parasitol 132: 90-6
  • Oeder S, Jorres RA, Weichenmeier I, Pusch G, Schober W, Pfab F, Behrendt H, Schierl R, Kronseder A, Nowak D, Dietrich S, Fernandez-Caldas E, Lintelmann J, Zimmermann R, Lang R, Mages J, Fromme H, Buters JT. 2012. Airborne indoor particles from schools are more toxic than outdoor particles. Am J Respir Cell Mol Biol 47: 575-82
  • Frankenberger M, Hofer TP, Marei A, Dayyani F, Schewe S, Strasser C, Aldraihim A, Stanzel F, Lang R, Hoffmann R, Prazeres da Costa O, Buch T, Ziegler-Heitbrock L. 2012. Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint. Eur J Immunol 42: 957-74
  • Al Masalma M, Lonjon M, Richet H, Dufour H, Roche PH, Drancourt M, Raoult D, Fournier PE. 2012. Metagenomic analysis of brain abscesses identifies specific bacterial associations. Clin Infect Dis 54: 202-10
  • Wenzel J, Held C, Palmisano R, Teufel S, David JP, Wittenberg T, Lang R. 2011. Measurement of TLR-Induced Macrophage Spreading by Automated Image Analysis: Differential Role of Myd88 and MAPK in Early and Late Responses. Front Physiol 2: 71
  • Strebovsky J, Walker P, Lang R, Dalpke AH. 2011. Suppressor of cytokine signaling 1 (SOCS1) limits NF kappa B signaling by decreasing p65 stability within the cell nucleus. Faseb Journal 25: 863-74
  • Lang R, Schoenen H, Desel C. 2011. Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions. Immunobiology 216: 1184-91
  • Kratochvill F, Machacek C, Vogl C, Ebner F, Sedlyarov V, Gruber AR, Hartweger H, Vielnascher R, Karaghiosoff M, Rulicke T, Muller M, Hofacker I, Lang R, Kovarik P. 2011. Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Mol Syst Biol 7: 560
  • Klotz C, Ziegler T, Figueiredo AS, Rausch S, Hepworth MR, Obsivac N, Sers C, Lang R, Hammerstein P, Lucius R, Hartmann S. 2011. A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS Pathog 7: e1001248
  • Jantsch J, Wiese M, Schodel J, Castiglione K, Glasner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C. 2011. Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1 alpha (HIF1A) and result in differential HIF1A-dependent gene expression. Journal of Leukocyte Biology 90: 551-62
  • Held C, Wenzel J, Webel R, Marschall M, Lang R, Palmisano R, Wittenberg T. 2011. Using multimodal information for the segmentation of fluorescent micrographs with application to virology and microbiology. Conf Proc IEEE Eng Med Biol Soc 2011: 6487-90
  • Weintz G, Olsen JV, Fruhauf K, Niedzielska M, Amit I, Jantsch J, Mages J, Frech C, Dolken L, Mann M, Lang R. 2010. The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6: 371
  • Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, Agger EM, Stenger S, Andersen P, Ruland J, Brown GD, Wells C, Lang R. 2010. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 184: 2756-60
  • Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R. 2010. Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. J Leukoc Biol 88: 579-87
  • Layland LE, Mages J, Loddenkemper C, Hoerauf A, Wagner H, Lang R, da Costa CUP. 2010. Pronounced Phenotype in Activated Regulatory T Cells during a Chronic Helminth Infection. Journal of Immunology 184: 713-24
  • Ingersoll MA, Spanbroek R, Lottaz C, Gautier EL, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht AJR, Ziegler-Heitbrock L, Randolph GJ. 2010. Comparison of gene expression profiles between human and mouse monocyte subsets. (vol 115, pg e10, 2010). Blood 116: 857
  • Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Mannel DN, Holzmann B, Lang R. 2010. Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 131: 395-404
  • Werninghaus K, Babiak A, Gross O, Holscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R. 2009. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med 206: 89-97
  • Schreiber T, Ehlers S, Heitmann L, Rausch A, Mages J, Murray PJ, Lang R, Holscher C. 2009. Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity. J Immunol 183: 1301-12
  • Schaljo B, Kratochvill F, Gratz N, Sadzak I, Sauer I, Hammer M, Vogl C, Strobl B, Muller M, Blackshear PJ, Poli V, Lang R, Murray PJ, Kovarik P. 2009. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183: 1197-206
  • Renstrom J, Istvanffy R, Gauthier K, Shimono A, Mages J, Jardon-Alvarez A, Kroger M, Schiemann M, Busch DH, Esposito I, Lang R, Peschel C, Oostendorp RA. 2009. Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. Cell Stem Cell 5: 157-67
  • Rad R, Ballhorn W, Voland P, Eisenacher K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, Bauer S, Prinz C, Kirschning CJ, Krug A. 2009. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136: 2247-57
  • Hertle ML, Popp C, Petermann S, Maier S, Kremmer E, Lang R, Mages J, Kempkes B. 2009. Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes. PLoS Pathog 5: e1000506
  • Andersen CA, Rosenkrands I, Olsen AW, Nordly P, Christensen D, Lang R, Kirschning C, Gomes JM, Bhowruth V, Minnikin DE, Besra GS, Follmann F, Andersen P, Agger EM. 2009. Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guerin. J Immunol 183: 2294-302
  • Aly S, Mages J, Reiling N, Kalinke U, Decker T, Lang R, Ehlers S. 2009. Mycobacteria-induced granuloma necrosis depends on IRF-1. Journal of Cellular and Molecular Medicine 13: 2069-82 von Burstin J, Eser S, Seidler B, Meining A, Bajbouj M, Mages J, Lang R, Kind AJ, Schnieke AE, Schmid RM, Schneider G, Saur D. 2008. Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. International Journal of Cancer 123: 2138-47
  • Rodriguez N, Lang R, Wantia N, Cirl C, Ertl T, Durr S, Wagner H, Miethke T. 2008. Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. Journal of Leukocyte Biology 84: 1585-93
  • Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Bruck W, Kalinke U. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28: 675-86
  • Mages J, Freimuller K, Lang R, Hatzopoulos AK, Guggemoos S, Koszinowski UH, Adler H. 2008. Proteins of the secretory pathway govern virus productivity during lytic gammaherpesvirus infection. Journal of Cellular and Molecular Medicine 12: 1974-89
  • Ledran MH, Krassowska A, Armstrong L, Dimmick I, Renstrom J, Lang R, Yung S, Santibanez-Coref M, Dzierzak E, Stojkovic M, Oostendorp RAJ, Forrester L, Lako M. 2008. Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell 3: 85-98
  • Kalali BN, Kollisch G, Mages J, Muller T, Bauer S, Wagner H, Ring J, Lang R, Mempel M, Ollert M. 2008. Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. J Immunol 181: 2694-704
  • Hofer TPJ, Frankenberger M, Mages J, Lang R, Hoffmann R, Colige A, Ziegler-Heitbrock L. 2008. Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids. Journal of Molecular Medicine-Jmm 86: 323-32
  • Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Roeschmann K, Jung G, Wiesmuller KH, Ulmer AJ. 2008. Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. Journal of Leukocyte Biology 83: 692-701
  • Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. 2008. Opposing functions of IKK beta during acute and chronic intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 105: 15058-63
  • Agger EM, Rosenkrands I, Hansen J, Brahimi K, Vandahl BS, Aagaard C, Werninghaus K, Kirschning C, Lang R, Christensen D, Theisen M, Follmann F, Andersen P. 2008. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PLoS One 3: e3116
  • Schmitz F, Heit A, Guggemoos S, Krug A, Mages J, Schiemann M, Adler H, Drexler I, Haas T, Lang R, Wagner H. 2007. Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Eur J Immunol 37: 315-27
  • Rodriguez N, Mages J, Dietrich H, Wantia N, Wagner H, Lang R, Miethke T. 2007. MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae. Physiol Genomics 30: 134-45
  • Rad R, Brenner L, Krug A, Voland P, Mages J, Lang R, Schwendy S, Reindl W, Dossumbekova A, Ballhorn W, Wagner H, Schmid RM, Bauer S, Prinz C. 2007. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133: 150-63 e3
  • Oeder S, Mages J, Flicek P, Lang R. 2007. Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets. BMC Genomics 8: 200 Mayer AK, Muehmer M, Mages J, Gueinzius K, Hess C, Heeg K, Bals R, Lang R, Dalpke AH. 2007. Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol 178: 3134-42
  • Mages J, Dietrich H, Lang R. 2007. A genome-wide analysis of LPS tolerance in macrophages. Immunobiology 212: 723-37
  • Aly S, Laskay T, Mages J, Malzan A, Lang R, Ehlers S. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212: 295-305
  • Weighardt H, Mages J, Jusek G, Kaiser-Moore S, Lang R, Holzmann B. 2006. Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis. Infect Immun 74: 3618-32
  • Maier S, Staffler G, Hartmann A, Hock J, Henning K, Grabusic K, Mailhammer R, Hoffmann R, Wilmanns M, Lang R, Mages J, Kempkes B. 2006. Cellular target genes of Epstein-Barr virus nuclear antigen 2. Journal of Virology 80: 9761-71
  • Lang R, Hammer M, Mages J. 2006. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol 177: 7497-504
  • Keller C, Hoffmann R, Lang R, Brandau S, Hermann C, Ehlers S. 2006. Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes. Infect Immun 74: 4295-309
  • Hammer M, Mages J, Dietrich H, Servatius A, Howells N, Cato AC, Lang R. 2006. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 203: 15-20
  • Dossumbekova A, Prinz C, Mages J, Lang R, Kusters JG, Van Vliet AHM, Reindl W, Backert S, Saur D, Schmid RM, Rad R. 2006. Helicobacter pylori HopH (OipA) and bacterial pathogenicity: Genetic and functional genomic analysis of hopH gene Polymorphisms. Journal of Infectious Diseases 194: 1346-55
  • Ludwig H, Mages J, Staib C, Lehmann MH, Lang R, Sutter G. 2005. Role of viral factor E3L in modified vaccinia virus Ankara infection of human HeLa cells: Regulation of the virus life cycle and identification of differentially expressed host genes. Journal of Virology 79: 2584-96
  • Lang R. 2005. Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection. Immunobiology 210: 63-76
  • Hammer M, Mages J, Dietrich H, Schmitz F, Striebel F, Murray PJ, Wagner H, Lang R. 2005. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur J Immunol 35: 2991-3001
  • Weighardt H, Jusek G, Mages J, Lang R, Hoebe K, Beutler B, Holzmann B. 2004. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. European Journal of Immunology 34: 558-64
  • Schmitz F, Mages J, Heit A, Lang R, Wagner H. 2004. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol 34: 2863-73
  • Rad R, Dossumbekova A, Neu B, Lang R, Bauer S, Saur D, Gerhard M, Prinz C. 2004. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 53: 1082-9
  • Pauleau AL, Rutschman R, Lang R, Pernis A, Watowich SS, Murray PJ. 2004. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol 172: 7565-73
  • Lang R, Pauleau AL, Parganas E, Takahashi Y, Mages J, Ihle JN, Rutschman R, Murray PJ. 2003. SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol 4: 546-50
  • Rad R, Gerhard M, Lang R, Schoniger M, Rosch T, Schepp W, Becker I, Wagner H, Prinz C. 2002. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. Journal of Immunology 168: 3033-41
  • Lang R, Rutschman RL, Greaves DR, Murray PJ. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol 168: 3402-11
  • Lang R, Patel D, Morris JJ, Rutschman RL, Murray PJ. 2002. Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol 169: 2253-63
  • Kornhuber ME, Ganz C, Lang R, Brill T, Schmahl W. 2002. Focal encephalitis in the Lewis rat induced by intracerebral enterotoxin superantigen and amplified by activated intravenous splenocytes. Neuroscience Letters 324: 93-6
  • Rutschman R, Lang R, Hesse M, Ihle JN, Wynn TA, Murray PJ. 2001. Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J Immunol 166: 2173-7
  • Kranzer K, Bauer M, Lipford GB, Heeg K, Wagner H, Lang R. 2000. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12. Immunology 99: 170-8
  • Lang R, Hultner L, Lipford GB, Wagner H, Heeg K. 1999. Guanosine-rich oligodeoxynucleotides induce proliferation of macrophage progenitors in cultures of murine bone marrow cells. European Journal of Immunology 29: 3496-506
  • Lang R, Heeg K. 1998. Semiquantitative determination of human cytokine mRna expression using TaqMan RT-PCR. Inflammopharmacology 6: 297-309
  • Lang R, Pfeffer K, Wagner H, Heeg K. 1997. A rapid method for semiquantitative analysis of the human V beta-repertoire using TaqMan(R) PCR. Journal of Immunological Methods 203: 181-92
  • Lang R, Wagner H, Heeg K. 1995. Differential-Effects of the Immunosuppressive Agents Cyclosporine and Leflunomide in-Vivo - Leflunomide Blocks Clonal T-Cell Expansion yet Allows Production of Lymphokines and Manifestation of T-Cell-Mediated Shock. Transplantation 59: 382-9