Publications

Microbiology

Head of Institute:
Prof. Dr. med. Christian Bogdan

1. Patin, E. C., S. Willcocks, S. Orr, T. H. Ward, R. Lang, and U. E. Schaible. 2016. Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immun 22: 181-185.

2. Huber, A., R. S. Kallerup, K. S. Korsholm, H. Franzyk, B. Lepenies, D. Christensen, C. Foged, and R. Lang. 2016. Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo. Innate Immunity accepted.

3. Wenzel, J., J. L. Ouderkirk, M. Krendel, and R. Lang. 2015. Class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release, and antigen presentation via MHC class II. European journal of immunology 45: 225-237.

4. Siegert, I., J. Schodel, M. Nairz, V. Schatz, K. Dettmer, C. Dick, J. Kalucka, K. Franke, M. Ehrenschwender, G. Schley, A. Beneke, J. Sutter, M. Moll, C. Hellerbrand, B. Wielockx, D. M. Katschinski, R. Lang, B. Galy, M. W. Hentze, P. Koivunen, P. J. Oefner, C. Bogdan, G. Weiss, C. Willam, and J. Jantsch. 2015. Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1alpha upon LPS Activation in the Presence of Ample Oxygen. Cell reports 13: 2048-2055.

5. Rabes, A., S. Zimmermann, K. Reppe, R. Lang, P. H. Seeberger, N. Suttorp, M. Witzenrath, B. Lepenies, and B. Opitz. 2015. The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response. PloS one 10.

6. Ostrop, J., K. Jozefowski, S. Zimmermann, K. Hofmann, E. Strasser, B. Lepenies, and R. Lang. 2015. Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB. Journal of immunology 195: 2417-2428.

7. Niedzielska, M., F. A. Raffi, J. Tel, S. Muench, K. Jozefowski, N. Alati, K. Lahl, J. Mages, U. Billmeier, M. Schiemann, U. K. Appelt, S. Wirtz, T. Sparwasser, H. Hochrein, C. G. Figdor, S. M. Keyse, and R. Lang. 2015. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. Journal of immunology 195: 1753-1762.

8. Goldmann, T., N. Zeller, J. Raasch, K. Kierdorf, K. Frenzel, L. Ketscher, A. Basters, O. Staszewski, S. M. Brendecke, A. Spiess, T. L. Tay, C. Kreutz, J. Timmer, G. M. Mancini, T. Blank, G. Fritz, K. Biber, R. Lang, D. Malo, D. Merkler, M. Heikenwalder, K. P. Knobeloch, and M. Prinz. 2015. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. The EMBO journal.

9. Schoenen, H., A. Huber, N. Sonda, S. Zimmermann, J. Jantsch, B. Lepenies, V. Bronte, and R. Lang. 2014. Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPbeta and HIF1alpha. Journal of immunology 193: 3664-3675.

10. Niedzielska, M., B. Bodendorfer, S. Munch, A. Eichner, M. Derigs, O. da Costa, A. Schweizer, F. Neff, L. Nitschke, T. Sparwasser, S. M. Keyse, and R. Lang. 2014. Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production. The Journal of biological chemistry 289: 2112-2126.

11. Goktuna, S. I., O. Canli, J. Bollrath, A. A. Fingerle, D. Horst, M. A. Diamanti, C. Pallangyo, M. Bennecke, T. Nebelsiek, A. K. Mankan, R. Lang, D. Artis, Y. Hu, T. Patzelt, J. Ruland, T. Kirchner, M. M. Taketo, A. Chariot, M. C. Arkan, and F. R. Greten. 2014. IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells. Cell reports 7: 1914-1925.

12. Globisch, T., N. Steiner, L. Fulle, V. Lukacs-Kornek, D. Degrandi, P. Dresing, J. Alferink, R. Lang, K. Pfeffer, M. Beyer, H. Weighardt, C. Kurts, T. Ulas, J. L. Schultze, and I. Forster. 2014. Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. European journal of immunology 44: 500-510.

13. Friedrich, O., B. Yi, J. N. Edwards, B. Reischl, A. Wirth-Hucking, A. Buttgereit, R. Lang, C. Weber, F. Polyak, I. Liu, F. von Wegner, T. R. Cully, A. Lee, P. Most, and M. Volkers. 2014. IL-1alpha reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy? American journal of respiratory cell and molecular biology 50: 1096-1106.

14. Schwitalla, S., A. A. Fingerle, P. Cammareri, T. Nebelsiek, S. I. Goktuna, P. K. Ziegler, O. Canli, J. Heijmans, D. J. Huels, G. Moreaux, R. A. Rupec, M. Gerhard, R. Schmid, N. Barker, H. Clevers, R. Lang, J. Neumann, T. Kirchner, M. M. Taketo, G. R. van den Brink, O. J. Sansom, M. C. Arkan, and F. R. Greten. 2013. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152: 25-38.

15. Puttur, F., C. Arnold-Schrauf, K. Lahl, G. Solmaz, M. Lindenberg, C. T. Mayer, M. Gohmert, M. Swallow, C. van Helt, H. Schmitt, L. Nitschke, B. N. Lambrecht, R. Lang, M. Messerle, and T. Sparwasser. 2013. Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. PLoS pathogens 9: e1003648.

16. Lang, R. 2013. Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis. Frontiers in immunology 4: 5.

17. Held, C., J. Wenzel, V. Wiesmann, R. Palmisano, R. Lang, and T. Wittenberg. 2013. Enhancing automated micrograph-based evaluation of LPS-stimulated macrophage spreading. Cytometry. Part A : the journal of the International Society for Analytical Cytology 83: 409-418.

18. Heitmann, L., H. Schoenen, S. Ehlers, R. Lang, and C. Holscher. 2013. Mincle is not essential for controlling Mycobacterium tuberculosis infection. Immunobiology 218: 506-516.

19. Desel, C., K. Werninghaus, M. Ritter, K. Jozefowski, J. Wenzel, N. Russkamp, U. Schleicher, D. Christensen, S. Wirtz, C. Kirschning, E. M. Agger, C. P. da Costa, and R. Lang. 2013. The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling. PloS one 8.

20. Specht, S., M. D. Taylor, M. A. Hoeve, J. E. Allen, R. Lang, and A. Hoerauf. 2012. Over expression of IL-10 by macrophages overcomes resistance to murine filariasis. Experimental parasitology 132: 90-96.

21. Oeder, S., R. A. Jorres, I. Weichenmeier, G. Pusch, W. Schober, F. Pfab, H. Behrendt, R. Schierl, A. Kronseder, D. Nowak, S. Dietrich, E. Fernandez-Caldas, J. Lintelmann, R. Zimmermann, R. Lang, J. Mages, H. Fromme, and J. T. Buters. 2012. Airborne indoor particles from schools are more toxic than outdoor particles. American journal of respiratory cell and molecular biology 47: 575-582.

22. Frankenberger, M., T. P. Hofer, A. Marei, F. Dayyani, S. Schewe, C. Strasser, A. Aldraihim, F. Stanzel, R. Lang, R. Hoffmann, O. Prazeres da Costa, T. Buch, and L. Ziegler-Heitbrock. 2012. Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint. European journal of immunology 42: 957-974.

23. Wenzel, J., C. Held, R. Palmisano, S. Teufel, J. P. David, T. Wittenberg, and R. Lang. 2011. Measurement of TLR-Induced Macrophage Spreading by Automated Image Analysis: Differential Role of Myd88 and MAPK in Early and Late Responses. Frontiers in physiology 2: 71.

24. Strebovsky, J., P. Walker, R. Lang, and A. H. Dalpke. 2011. Suppressor of cytokine signaling 1 (SOCS1) limits NF kappa B signaling by decreasing p65 stability within the cell nucleus. Faseb J 25: 863-874.

25. Lang, R., H. Schoenen, and C. Desel. 2011. Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: Findings, implications and open questions. Immunobiology 216: 1184-1191.

26. Kratochvill, F., C. Machacek, C. Vogl, F. Ebner, V. Sedlyarov, A. R. Gruber, H. Hartweger, R. Vielnascher, M. Karaghiosoff, T. Rulicke, M. Muller, I. Hofacker, R. Lang, and P. Kovarik. 2011. Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Molecular systems biology 7: 560.

27. Klotz, C., T. Ziegler, A. S. Figueiredo, S. Rausch, M. R. Hepworth, N. Obsivac, C. Sers, R. Lang, P. Hammerstein, R. Lucius, and S. Hartmann. 2011. A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS pathogens 7: e1001248.

28. Jantsch, J., M. Wiese, J. Schodel, K. Castiglione, J. Glasner, S. Kolbe, D. Mole, U. Schleicher, K. U. Eckardt, M. Hensel, R. Lang, C. Bogdan, M. Schnare, and C. Willam. 2011. Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1 alpha (HIF1A) and result in differential HIF1A-dependent gene expression. Journal of leukocyte biology 90: 551-562.

29. Weintz, G., J. V. Olsen, K. Fruhauf, M. Niedzielska, I. Amit, J. Jantsch, J. Mages, C. Frech, L. Dolken, M. Mann, and R. Lang. 2010. The phosphoproteome of toll-like receptor-activated macrophages. Molecular systems biology 6: 371.

30. Schoenen, H., B. Bodendorfer, K. Hitchens, S. Manzanero, K. Werninghaus, F. Nimmerjahn, E. M. Agger, S. Stenger, P. Andersen, J. Ruland, G. D. Brown, C. Wells, and R. Lang. 2010. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. Journal of immunology 184: 2756-2760.

31. Rodriguez, N., H. Dietrich, I. Mossbrugger, G. Weintz, J. Scheller, M. Hammer, L. Quintanilla-Martinez, S. Rose-John, T. Miethke, and R. Lang. 2010. Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. Journal of leukocyte biology 88: 579-587.

32. Layland, L. E., J. Mages, C. Loddenkemper, A. Hoerauf, H. Wagner, R. Lang, and C. U. P. da Costa. 2010. Pronounced Phenotype in Activated Regulatory T Cells during a Chronic Helminth Infection. Journal of immunology 184: 713-724.

33. Ingersoll, M. A., R. Spanbroek, C. Lottaz, E. L. Gautier, M. Frankenberger, R. Hoffmann, R. Lang, M. Haniffa, M. Collin, F. Tacke, A. J. R. Habenicht, L. Ziegler-Heitbrock, and G. J. Randolph. 2010. Comparison of gene expression profiles between human and mouse monocyte subsets. (vol 115, pg e10, 2010). Blood 116: 857-857.

34. Hammer, M., B. Echtenachter, H. Weighardt, K. Jozefowski, S. Rose-John, D. N. Mannel, B. Holzmann, and R. Lang. 2010. Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 131: 395-404.

35. Werninghaus, K., A. Babiak, O. Gross, C. Holscher, H. Dietrich, E. M. Agger, J. Mages, A. Mocsai, H. Schoenen, K. Finger, F. Nimmerjahn, G. D. Brown, C. Kirschning, A. Heit, P. Andersen, H. Wagner, J. Ruland, and R. Lang. 2009. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. The Journal of experimental medicine 206: 89-97.

36. Schreiber, T., S. Ehlers, L. Heitmann, A. Rausch, J. Mages, P. J. Murray, R. Lang, and C. Holscher. 2009. Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity. Journal of immunology 183: 1301-1312.

37. Schaljo, B., F. Kratochvill, N. Gratz, I. Sadzak, I. Sauer, M. Hammer, C. Vogl, B. Strobl, M. Muller, P. J. Blackshear, V. Poli, R. Lang, P. J. Murray, and P. Kovarik. 2009. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. Journal of immunology 183: 1197-1206.

38. Rad, R., W. Ballhorn, P. Voland, K. Eisenacher, J. Mages, L. Rad, R. Ferstl, R. Lang, H. Wagner, R. M. Schmid, S. Bauer, C. Prinz, C. J. Kirschning, and A. Krug. 2009. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136: 2247-2257.

39. Hertle, M. L., C. Popp, S. Petermann, S. Maier, E. Kremmer, R. Lang, J. Mages, and B. Kempkes. 2009. Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes. PLoS pathogens 5: e1000506.

40. Andersen, C. A., I. Rosenkrands, A. W. Olsen, P. Nordly, D. Christensen, R. Lang, C. Kirschning, J. M. Gomes, V. Bhowruth, D. E. Minnikin, G. S. Besra, F. Follmann, P. Andersen, and E. M. Agger. 2009. Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guerin. Journal of immunology 183: 2294-2302.

41. Aly, S., J. Mages, N. Reiling, U. Kalinke, T. Decker, R. Lang, and S. Ehlers. 2009. Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13: 2069-2082.

42. von Burstin, J., S. Eser, B. Seidler, A. Meining, M. Bajbouj, J. Mages, R. Lang, A. J. Kind, A. E. Schnieke, R. M. Schmid, G. Schneider, and D. Saur. 2008. Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. Int J Cancer 123: 2138-2147.

43. Rodriguez, N., R. Lang, N. Wantia, C. Cirl, T. Ertl, S. Durr, H. Wagner, and T. Miethke. 2008. Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. Journal of leukocyte biology 84: 1585-1593.

44. Prinz, M., H. Schmidt, A. Mildner, K. P. Knobeloch, U. K. Hanisch, J. Raasch, D. Merkler, C. Detje, I. Gutcher, J. Mages, R. Lang, R. Martin, R. Gold, B. Becher, W. Bruck, and U. Kalinke. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28: 675-686.

45. Mages, J., K. Freimuller, R. Lang, A. K. Hatzopoulos, S. Guggemoos, U. H. Koszinowski, and H. Adler. 2008. Proteins of the secretory pathway govern virus productivity during lytic gammaherpesvirus infection. J Cell Mol Med 12: 1974-1989.

46. Ledran, M. H., A. Krassowska, L. Armstrong, I. Dimmick, J. Renstrom, R. Lang, S. Yung, M. Santibanez-Coref, E. Dzierzak, M. Stojkovic, R. A. J. Oostendorp, L. Forrester, and M. Lako. 2008. Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell 3: 85-98.

47. Kalali, B. N., G. Kollisch, J. Mages, T. Muller, S. Bauer, H. Wagner, J. Ring, R. Lang, M. Mempel, and M. Ollert. 2008. Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. Journal of immunology 181: 2694-2704.

48. Hofer, T. P. J., M. Frankenberger, J. Mages, R. Lang, R. Hoffmann, A. Colige, and L. Ziegler-Heitbrock. 2008. Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids. J Mol Med-Jmm 86: 323-332.

49. Farhat, K., S. Riekenberg, H. Heine, J. Debarry, R. Lang, J. Mages, U. Buwitt-Beckmann, K. Roeschmann, G. Jung, K. H. Wiesmuller, and A. J. Ulmer. 2008. Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. Journal of leukocyte biology 83: 692-701.

50. Eckmann, L., T. Nebelsiek, A. A. Fingerle, S. M. Dann, J. Mages, R. Lang, S. Robine, M. F. Kagnoff, R. M. Schmid, M. Karin, M. C. Arkan, and F. R. Greten. 2008. Opposing functions of IKK beta during acute and chronic intestinal inflammation. P Natl Acad Sci USA 105: 15058-15063.

51. Agger, E. M., I. Rosenkrands, J. Hansen, K. Brahimi, B. S. Vandahl, C. Aagaard, K. Werninghaus, C. Kirschning, R. Lang, D. Christensen, M. Theisen, F. Follmann, and P. Andersen. 2008. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PloS one 3: e3116.

52. Schmitz, F., A. Heit, S. Guggemoos, A. Krug, J. Mages, M. Schiemann, H. Adler, I. Drexler, T. Haas, R. Lang, and H. Wagner. 2007. Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. European journal of immunology 37: 315-327.

53. Rodriguez, N., J. Mages, H. Dietrich, N. Wantia, H. Wagner, R. Lang, and T. Miethke. 2007. MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae. Physiological genomics 30: 134-145.

54. Rad, R., L. Brenner, A. Krug, P. Voland, J. Mages, R. Lang, S. Schwendy, W. Reindl, A. Dossumbekova, W. Ballhorn, H. Wagner, R. M. Schmid, S. Bauer, and C. Prinz. 2007. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133: 150-163 e153.

55. Mayer, A. K., M. Muehmer, J. Mages, K. Gueinzius, C. Hess, K. Heeg, R. Bals, R. Lang, and A. H. Dalpke. 2007. Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. Journal of immunology 178: 3134-3142.

56. Mages, J., H. Dietrich, and R. Lang. 2007. A genome-wide analysis of LPS tolerance in macrophages. Immunobiology 212: 723-737.

57. Aly, S., T. Laskay, J. Mages, A. Malzan, R. Lang, and S. Ehlers. 2007. Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. The Journal of pathology 212: 295-305.

58. Weighardt, H., J. Mages, G. Jusek, S. Kaiser-Moore, R. Lang, and B. Holzmann. 2006. Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis. Infection and immunity 74: 3618-3632.

59. Maier, S., G. Staffler, A. Hartmann, J. Hock, K. Henning, K. Grabusic, R. Mailhammer, R. Hoffmann, M. Wilmanns, R. Lang, J. Mages, and B. Kempkes. 2006. Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol 80: 9761-9771.

60. Lang, R., M. Hammer, and J. Mages. 2006. DUSP meet immunology: Dual specificity MAPK phosphatases in control of the inflammatory response. Journal of immunology 177: 7497-7504.

61. Keller, C., R. Hoffmann, R. Lang, S. Brandau, C. Hermann, and S. Ehlers. 2006. Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes. Infection and immunity 74: 4295-4309.

62. Hammer, M., J. Mages, H. Dietrich, A. Servatius, N. Howells, A. C. Cato, and R. Lang. 2006. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. The Journal of experimental medicine 203: 15-20.

63. Dossumbekova, A., C. Prinz, J. Mages, R. Lang, J. G. Kusters, A. H. M. Van Vliet, W. Reindl, S. Backert, D. Saur, R. M. Schmid, and R. Rad. 2006. Helicobacter pylori HopH (OipA) and bacterial pathogenicity: Genetic and functional genomic analysis of hopH gene Polymorphisms. J Infect Dis 194: 1346-1355.

64. Ludwig, H., J. Mages, C. Staib, M. H. Lehmann, R. Lang, and G. Sutter. 2005. Role of viral factor E3L in modified vaccinia virus Ankara infection of human HeLa cells: Regulation of the virus life cycle and identification of differentially expressed host genes. J Virol 79: 2584-2596.

65. Lang, R. 2005. Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection. Immunobiology 210: 63-76.

66. Hammer, M., J. Mages, H. Dietrich, F. Schmitz, F. Striebel, P. J. Murray, H. Wagner, and R. Lang. 2005. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. European journal of immunology 35: 2991-3001.

67. Weighardt, H., G. Jusek, J. Mages, R. Lang, K. Hoebe, B. Beutler, and B. Holzmann. 2004. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. European journal of immunology 34: 558-564.

68. Schmitz, F., J. Mages, A. Heit, R. Lang, and H. Wagner. 2004. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. European journal of immunology 34: 2863-2873.

69. Schmitz, F., J. Mages, A. Heit, R. Lang, and H. Wagner. 2004. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. European journal of immunology 34: 2863-2873.

70. Rad, R., A. Dossumbekova, B. Neu, R. Lang, S. Bauer, D. Saur, M. Gerhard, and C. Prinz. 2004. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 53: 1082-1089.

71. Pauleau, A. L., R. Rutschman, R. Lang, A. Pernis, S. S. Watowich, and P. J. Murray. 2004. Enhancer-mediated control of macrophage-specific arginase I expression. Journal of immunology 172: 7565-7573.

72. Lang, R., A. L. Pauleau, E. Parganas, Y. Takahashi, J. Mages, J. N. Ihle, R. Rutschman, and P. J. Murray. 2003. SOCS3 regulates the plasticity of gp130 signaling. Nature immunology 4: 546-550.

73. Rad, R., M. Gerhard, R. Lang, M. Schoniger, T. Rosch, W. Schepp, I. Becker, H. Wagner, and C. Prinz. 2002. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. Journal of immunology 168: 3033-3041.

74. Lang, R., R. L. Rutschman, D. R. Greaves, and P. J. Murray. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. Journal of immunology 168: 3402-3411.

75. Lang, R., D. Patel, J. J. Morris, R. L. Rutschman, and P. J. Murray. 2002. Shaping gene expression in activated and resting primary macrophages by IL-10. Journal of immunology 169: 2253-2263.

76. Kornhuber, M. E., C. Ganz, R. Lang, T. Brill, and W. Schmahl. 2002. Focal encephalitis in the Lewis rat induced by intracerebral enterotoxin superantigen and amplified by activated intravenous splenocytes. Neurosci Lett 324: 93-96.

77. Rutschman, R., R. Lang, M. Hesse, J. N. Ihle, T. A. Wynn, and P. J. Murray. 2001. Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. Journal of immunology 166: 2173-2177.

78. Kranzer, K., M. Bauer, G. B. Lipford, K. Heeg, H. Wagner, and R. Lang. 2000. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12. Immunology 99: 170-178.

79. Lang, R., L. Hultner, G. B. Lipford, H. Wagner, and K. Heeg. 1999. Guanosine-rich oligodeoxynucleotides induce proliferation of macrophage progenitors in cultures of murine bone marrow cells. European journal of immunology 29: 3496-3506.

80. Lang, R., K. Pfeffer, H. Wagner, and K. Heeg. 1997. A rapid method for semiquantitative analysis of the human V beta-repertoire using TaqMan(R) PCR. J Immunol Methods 203: 181-192.

81. Lang, R. 1996. Leflunomide - A viewpoint. Clin Immunother 6: 306-306.

82. Lang, R., H. Wagner, and K. Heeg. 1995. Differential-Effects of the Immunosuppressive Agents Cyclosporine and Leflunomide in-Vivo - Leflunomide Blocks Clonal T-Cell Expansion yet Allows Production of Lymphokines and Manifestation of T-Cell-Mediated Shock. Transplantation 59: 382-389.

 
 
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Summary