Visitenkarte

Mikrobiologie

Direktor:
Prof. Dr. med. Christian Bogdan
Portrait-Foto von Prof. Dr. med. Roland Lang

Prof. Dr. med. Roland Lang

Telefon:
09131 85-22979
DECT:
09131 85-46904
Faxnummer:
09131 85-22573


Einrichtung:
Position:
Stellvertretender Institutsdirektor
 

Professur für Angeborene Immunität und Pathogenerkennung

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Publikationen

  1. Weintz, G., Olsen, J.V., Frühauf, K., Niedzielska, M., Amit, I., Jantsch J., Mages, J., Frech, C., Dölken, L., Mann, M., Lang, R. (2010) The Phosphoproteome of Toll-like Receptor (TLR)-Activated Macrophages Mol Syst Biol accepted.
  2. Rodriguez, N., Dietrich, H., Mossbrugger, I., Weintz, G., Scheller, J., Hammer, M., Quintanilla-Martinez, L., Rose-John, S., Miethke, T., and Lang, R. (2010) Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1-/- mice: critical role of IL-6. Journal of Leukocyte Biology accepted.
  3. Hammer, M., Echtenachter, B., Weighardt, H., Jozefowski, K., Männel, D., Holzmann, B., Lang, R. (2010) Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology accepted.
  4. Ingersoll, M.A., Spanbroek, R., Lottaz, C., Gautier, E.L., Frankenberger, M., Hoffmann, R., Lang, R., Haniffa, M., Collin, M., Tacke, F., Habenicht, A.J., Ziegler-Heitbrock, L., Randolph, G.J. (2010) Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115, e10-9.
  5. Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E.M., Stenger, S., Andersen, P., Ruland, J., Brown, G.D., Wells, C., Lang, R. (2010) Cutting edge: mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 184, 2756-60.
  6. Layland, L.E., Mages, J., Loddenkemper, C., Hoerauf, A., Wagner, H., Lang, R., da Costa, C.U. (2010) Pronounced phenotype in activated regulatory T cells during a chronic helminth infection. J Immunol 184, 713-24.
  7. Werninghaus, K., Babiak, A., Gross, O., Holscher, C., Dietrich, H., Agger, E.M., Mages, J., Mocsai, A., Schoenen, H., Finger, K., Nimmerjahn, F., Brown, G.D., Kirschning, C., Heit, A., Andersen, P., Wagner, H., Ruland, J., Lang, R. (2009) Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med 206, 89-97.
  8. Schreiber, T., Ehlers, S., Heitmann, L., Rausch, A., Mages, J., Murray, P.J., Lang, R., Holscher, C. (2009) Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity. J Immunol 183, 1301-12.
  9. Hertle, M.L., Popp, C., Petermann, S., Maier, S., Kremmer, E., Lang, R., Mages, J., Kempkes, B. (2009) Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes. PLoS Pathog 5, e1000506.
  10. Rad, R., Ballhorn, W., Voland, P., Eisenacher, K., Mages, J., Rad, L., Ferstl, R., Lang, R., Wagner, H., Schmid, R.M., Bauer, S., Prinz, C., Kirschning, C.J., Krug, A. (2009) Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136, 2247-57.
  11. Aly, S., Mages, J., Reiling, N., Kalinke, U., Decker, T., Lang, R., Ehlers, S. (2009) Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13, 2069-82.
  12. Andersen, C.A., Rosenkrands, I., Olsen, A.W., Nordly, P., Christensen, D., Lang, R., Kirschning, C., Gomes, J.M., Bhowruth, V., Minnikin, D.E., Besra, G.S., Follmann, F., Andersen, P., Agger, E.M. (2009) Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guerin. J Immunol 183, 2294-302.
  13. Renstrom, J., Istvanffy, R., Gauthier, K., Shimono, A., Mages, J., Jardon-Alvarez, A., Kroger, M., Schiemann, M., Busch, D.H., Esposito, I., Lang, R., Peschel, C., Oostendorp, R.A. (2009) Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. Cell Stem Cell 5, 157-67.
  14. Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Muller, M., Blackshear, P.J., Poli, V., Lang, R., Murray, P.J., Kovarik, P. (2009) Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183, 1197-206.
  15. Agger, E.M., Rosenkrands, I., Hansen, J., Brahimi, K., Vandahl, B.S., Aagaard, C., Werninghaus, K., Kirschning, C., Lang, R., Christensen, D., Theisen, M., Follmann, F., Andersen, P. (2008) Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PLoS ONE 3, e3116.
  16. Prinz, M., Schmidt, H., Mildner, A., Knobeloch, K.P., Hanisch, U.K., Raasch, J., Merkler, D., Detje, C., Gutcher, I., Mages, J., Lang, R., Martin, R., Gold, R., Becher, B., Bruck, W., Kalinke, U. (2008) Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28, 675-86.
  17. Kalali, B.N., Kollisch, G., Mages, J., Muller, T., Bauer, S., Wagner, H., Ring, J., Lang, R., Mempel, M., Ollert, M. (2008) Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. J Immunol 181, 2694-704.
  18. Ledran, M.H., Krassowska, A., Armstrong, L., Dimmick, I., Renstrom, J., Lang, R., Yung, S., Santibanez-Coref, M., Dzierzak, E., Stojkovic, M., Oostendorp, R.A., Forrester, L., Lako, M. (2008) Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell 3, 85-98.
  19. Farhat, K., Riekenberg, S., Heine, H., Debarry, J., Lang, R., Mages, J., Buwitt-Beckmann, U., Roschmann, K., Jung, G., Wiesmuller, K.H., Ulmer, A.J. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J Leukoc Biol 83, 692-701.
  20. von Burstin, J., Eser, S., Seidler, B., Meining, A., Bajbouj, M., Mages, J., Lang, R., Kind, A.J., Schnieke, A.E., Schmid, R.M., Schneider, G., Saur, D. (2008) Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. Int J Cancer 123, 2138-47.
  21. Rodriguez, N., Lang, R., Wantia, N., Cirl, C., Ertl, T., Durr, S., Wagner, H., Miethke, T. (2008) Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. J Leukoc Biol 84, 1585-93.
  22. Eckmann, L., Nebelsiek, T., Fingerle, A.A., Dann, S.M., Mages, J., Lang, R., Robine, S., Kagnoff, M.F., Schmid, R.M., Karin, M., Arkan, M.C., Greten, F.R. (2008) Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A 105, 15058-63.
  23. Mages, J., Freimuller, K., Lang, R., Hatzopoulos, A.K., Guggemoos, S., Koszinowski, U.H., Adler, H. (2008) Proteins of the Secretory Pathway Govern Virus Productivity During Lytic Gammaherpesvirus Infection. J Cell Mol Med.
  24. Hofer, T.P., Frankenberger, M., Mages, J., Lang, R., Hoffmann, R., Colige, A., Ziegler-Heitbrock, L. (2008) Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids. J Mol Med 86, 323-32.
  25. Mayer, A.K., Muehmer, M., Mages, J., Gueinzius, K., Hess, C., Heeg, K., Bals, R., Lang, R., Dalpke, A.H. (2007) Differential Recognition of TLR-Dependent Microbial Ligands in Human Bronchial Epithelial Cells. J Immunol 178, 3134-42.
  26. Mages, J., Dietrich, H., Lang, R. (2007) A genome-wide analysis of LPS tolerance in macrophages. Immunobiology 212 , 723-37.
  27. Aly, S., Laskay, T., Mages, J., Malzan, A., Lang, R., Ehlers, S. (2007) Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis. J Pathol 212, 295-305.
  28. Schmitz, F., Heit, A., Guggemoos, S., Krug, A., Mages, J., Schiemann, M., Adler, H., Drexler, I., Haas, T., Lang, R., Wagner, H. (2007) Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Eur J Immunol 37, 315-27.
  29. Rodriguez, N., Mages, J., Dietrich, H., Wantia, N., Wagner, H., Lang, R., Miethke, T. (2007) MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae. Physiol Genomics 30, 134-45.
  30. Rad, R., Brenner, L., Krug, A., Voland, P., Mages, J., Lang, R., Schwendy, S., Reindl, W., Dossumbekova, A., Ballhorn, W., Wagner, H., Schmid, R.M., Bauer, S., Prinz, C. (2007) Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133, 150-163 e3.
  31. Oeder, S., Mages, J., Flicek, P., Lang, R. (2007) Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets. BMC Genomics 8, 200.
  32. Maier, S., Staffler, G., Hartmann, A., Hock, J., Henning, K., Grabusic, K., Mailhammer, R., Hoffmann, R., Wilmanns, M., Lang, R., Mages, J., Kempkes, B. (2006) Cellular target genes of epstein-barr virus nuclear antigen 2. J Virol 80, 9761-71.
  33. Hammer, M., Mages, J., Dietrich, H., Servatius, A., Howells, N., Cato, A.C., Lang, R. (2006) Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 203, 15-20.
  34. Lang, R., Hammer, M., Mages, J. (2006) DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol 177, 7497-504.
  35. Keller, C., Hoffmann, R., Lang, R., Brandau, S., Hermann, C., Ehlers, S. (2006) Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes. Infect Immun 74, 4295-309.
  36. Dossumbekova, A., Prinz, C., Mages, J., Lang, R., Kusters, J.G., Van Vliet, A.H., Reindl, W., Backert, S., Saur, D., Schmid, R.M., Rad, R. (2006) Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms. J Infect Dis 194, 1346-55.
  37. Weighardt, H., Mages, J., Jusek, G., Kaiser-Moore, S., Lang, R., Holzmann, B. (2006) Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis. Infect Immun 74, 3618-32.
  38. 38. Hammer, M., Mages, J., Dietrich, H., Schmitz, F., Striebel, F., Murray, P.J., Wagner, H., Lang, R. (2005) Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur J Immunol 35, 2991-3001.
  39. Ludwig, H., Mages, J., Staib, C., Lehmann, M.H., Lang, R., Sutter, G. (2005) Role of viral factor E3L in modified vaccinia virus ankara infection of human HeLa Cells: regulation of the virus life cycle and identification of differentially expressed host genes. J Virol 79, 2584-96.
  40. Lang, R. (2005) Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection. Immunobiology 210, 63-76.
  41. Andreansky, S., Liu, H., Turner, S., McCullers, J.A., Lang, R., Rutschman, R., Doherty, P.C., Murray, P.J., Nienhuis, A.W., Strom, T.S. (2005) WASP(-) mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. Exp Hematol 33, 443-51.
  42. Rad, R., Dossumbekova, A., Neu, B., Lang, R., Bauer, S., Saur, D., Gerhard, M., Prinz, C. (2004) Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 53, 1082-9.
  43. Pauleau, A.L., Rutschman, R., Lang, R., Pernis, A., Watowich, S.S., Murray, P.J. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol 172, 7565-73.
  44. Weighardt, H., Jusek, G., Mages, J., Lang, R., Hoebe, K., Beutler, B., Holzmann, B. (2004) Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur J Immunol 34, 558-64.
  45. Schmitz, F., Mages, J., Heit, A., Lang, R., Wagner, H. (2004) Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol 34, 2863-73.
  46. Lang, R., Pauleau, A.L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J.N., Rutschman, R., Murray, P.J. (2003) SOCS3 regulates the plasticity of gp130 signaling. Nat Immunol 4, 546-50.
  47. Lang, R., Rutschman, R.L., Greaves, D.R., Murray, P.J. (2002) Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol 168, 3402-11.
  48. Kornhuber, M.E., Ganz, C., Lang, R., Brill, T., Schmahl, W. (2002) Focal encephalitis in the Lewis rat induced by intracerebral enterotoxin superantigen and amplified by activated intravenous splenocytes. Neurosci Lett 324, 93-6.
  49. Rad, R., Gerhard, M., Lang, R., Schoniger, M., Rosch, T., Schepp, W., Becker, I., Wagner, H., Prinz, C. (2002) The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. J Immunol 168, 3033-41.
  50. Lang, R., Patel, D., Morris, J.J., Rutschman, R.L., Murray, P.J. (2002) Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol 169, 2253-63.
  51. Rutschman, R., Lang, R., Hesse, M., Ihle, J.N., Wynn, T.A., Murray, P.J. (2001) Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J Immunol 166, 2173-7.
  52. Kranzer, K., Bauer, M., Lipford, G.B., Heeg, K., Wagner, H., Lang, R. (2000) CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon- gamma production and up-regulation of CD69 via induction of antigen- presenting cell-derived interferon type I and interleukin-12. Immunology 99, 170-8.
  53. Lang, R., Hultner, L., Lipford, G.B., Wagner, H., Heeg, K. (1999) Guanosine-rich oligodeoxynucleotides induce proliferation of macrophage progenitors in cultures of murine bone marrow cells. Eur J Immunol 29, 3496-506.
 
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