Invasive fungal infections have gained increasing clinical importance over the past decades, mainly based on the fact that the numbers of patients at risk, i.e. immunocompromised individuals, have steadily risen. Among the main fungal pathogens, Aspergillus species have emerged as a severe threat for susceptible patients, as infections by this ubiquitous mould are often diagnosed late and when therapeutic options are limited. A. fumigatus is evident as the main pathogenic species among aspergilli, and current research approaches focus on fungal traits, commonly termed as the virulome, as well as host factors that promote onset and progression of aspergillosis.
Current projects of the research group focus on different aspects of the Aspergillus lifecycle, such as fungal virulence determinants for invasive aspergillosis, the pathogen-host interaction during haematogenous dissemination, and the extant sexual cycle of A. fumigatus; moreover, methods and tools are constantly developed and improved with the aim to enhance means of Aspergillus molecular biology.