Relevant publications

Microbiology

Head of Institute:
Prof. Dr. med. Christian Bogdan

Relevant Publications

NK cells and TLR9 in leishmaniasis  

  • Bogdan C. Natural killer cells in experimental and human leishmaniasis. Front Cell Infect Microbiol. 2012 May 29;2:69.
  • Chittappen, K.P., Häberlein, S., Sebald, H., Schleicher, U., Bogdan, Ch.: Leishmania-infected macrophages are target of NK cell-derived cytokines but not of NK cell cytotoxicity. 2011. Infect. Immun. 79 : 2699-2708.
  • Haeberlein S, Sebald H, Bogdan C, Schleicher U. 2010. IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo. Eur J Immunol 40(6):1708-1717.
  • Liese, J., U. Schleicher, and C. Bogdan. 2008. The innate immune response against Leishmania parasites. Immunobiology 213:377-387.
  • Liese, J., U. Schleicher, and C. Bogdan. 2007. TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. Eur J Immunol 37:3424-3434.
  • Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J.A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204:893-906.
  • Mattner, J., N. Donhauser, G. Werner-Felmayer, and C. Bogdan. 2006. NKT cells mediate organ-specific resistance against Leishmania major infection. Microbes Infect 8:354-362.
  • Schleicher, U., J. Mattner, M. Blos, H. Schindler, M. Rollinghoff, M. Karaghiosoff, M. Muller, G. Werner-Felmayer, and C. Bogdan. 2004. Control of Leishmania major in the absence of Tyk2 kinase. Eur J Immunol 34:519-529.
  • Mattner, J., H. Schindler, A. Diefenbach, M. Röllinghoff, I. Gresser, and C. Bogdan. 2000. Regulation of type 2 NO synthase by type I interferons in macrophages infected with Leishmania major. Eur. J. Immunol. 30:2257-2267.
  • Diefenbach, A., H. Schindler, N. Donhauser, E. Lorenz, T. Laskay, J. MacMicking, M. Röllinghoff, I. Gresser, and C. Bogdan. 1998. Type 1 interferon (IFN-a/b) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8:77-87.

Inducible NO synthase, arginase and reactive oxygen intermediates

  • Mahnke A, Meier RJ, Schatz V, Hofmann J, Castiglione K, Schleicher U, Wolfbeis OS, Bogdan C, Jantsch J. Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages. J Invest Dermatol. 2014 Feb 28. doi: 10.1038/jid.2014.121.
  • Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G. Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection. J Exp Med. 2013 May 6;210(5):855-73.
  • Bogdan C. Listeria monocytogenes: no spreading without NO. Immunity. 2012 May 25;36(5):697-9.
  • Wiese M, Gerlach RG, Popp I, Matuszak J, Mahapatro M, Castiglione K, Chakravortty D, Willam C, Hensel M, Bogdan C, Jantsch J. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun. 2012 Apr;80(4):1455-66
  • Bogdan, Ch.: Regulation of lymphocytes by nitric oxide. 2011 Methods Mol. Biol. 677 : 375-93.
  • Bogdan C. 2011. Reactive oxygen and reactive nitrogen intermediates in the immune system, p 69–84 In Kaufmann SH, Rouse B, Sacks D, editors. (ed), Immunology of infectious diseases. ASM Press, Washington, DC
  • Fritzsche, C., U. Schleicher, and C. Bogdan. 2010. Endothelial NO synthase limits the inflammatory response in mouse cutaneous leishmaniasis. Immunobiology 215:826-832.
  • König T, Bogdan C, Schleicher U. Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2alpha. Immunobiology. 2009;214(9-10):822-7.
  • El Kasmi, K.C., J.E. Qualls, J.T. Pesce, A.M. Smith, R.W. Thompson, M. Henao-Tamayo, R.J. Basaraba, T. Konig, U. Schleicher, M.S. Koo, G. Kaplan, K.A. Fitzgerald, E.I. Tuomanen, I.M. Orme, T.D. Kanneganti, C. Bogdan, T.A. Wynn, and P.J. Murray. 2008. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol 9:1399-1406.
  • Valdez, C.A., J.E. Saavedra, B.M. Showalter, K.M. Davies, T.C. Wilde, M.L. Citro, J.J. Barchi, Jr., J.R. Deschamps, D. Parrish, S. El-Gayar, U. Schleicher, C. Bogdan, and L.K. Keefer. 2008. Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity. J Med Chem 51:3961-3970.
  • Bogdan C. 2008. Mechanisms and consequences of persistence of intracellular pathogens: leishmaniasis as an example. Cell Microbiol. 2008 Jun;10(6):1221-34. Epub 2008 Mar 17.
  • Bogdan C. Phagocyte Effector Functions against Leishmania Parasites. 2007. In: Protozoans in Macrophages (eds. E. Denkers and R. Gazzinelli), Landes Bioscience
  • Rocha, F.J., U. Schleicher, J. Mattner, G. Alber, and C. Bogdan. 2007. Cytokines, Signaling Pathways, and Effector Molecules Required for the Control of Leishmania (Viannia) braziliensis in Mice. Infect Immun 75:3823-3832.
  • Bogdan C. 2004. Reactive oxygen and reactive nitrogen metabolites as effector molecules against infectious pathogens. In: The Innate Immune Response to Infection (ed. by S.H.E. Kaufmann, R. Medzhitov, and S. Gordon), ASM Press, Washington, DC, pp. 357-396
  • El-Gayar, S., H. Thuring-Nahler, J. Pfeilschifter, M. Rollinghoff, and C. Bogdan. 2003. Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages. J Immunol 171:4561-4568.
  • Blos, M., U. Schleicher, F.J. Soares Rocha, U. Meissner, M. Rollinghoff, and C. Bogdan. 2003. Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase. Eur J Immunol 33:1224-1234.
  • Bogdan, C. 2001. Nitric oxide and the immune response. Nat Immunol 2:907-916.
  • Bogdan, C., M. Röllinghoff, and A. Diefenbach. 2000. The role of nitric oxide in innate immunity. Immunol. Reviews 173:17-26.
  • Bogdan, C., N. Donhauser, R. Döring, M. Röllinghoff, A. Diefenbach, and M.G. Rittig. 2000. Fibroblasts as host cells in latent leishmaniosis. J. Exp. Med. 191:2121-2129.
  • Diefenbach, A., H. Schindler, M. Röllinghoff, W. Yokoyama, and C. Bogdan. 1999. Requirement for type 2 NO-synthase for IL-12 responsiveness in innate immunity. Science 284:951-955.
  • Diefenbach, A., H. Schindler, N. Donhauser, E. Lorenz, T. Laskay, J. MacMicking, M. Röllinghoff, I. Gresser, and C. Bogdan. 1998. Type 1 interferon (IFN-a/b) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8:77-87.
  • Stenger, S., N. Donhauser, H. Thüring, M. Röllinghoff, and C. Bogdan. 1996. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J. Exp. Med. 183:1501-1514.

Type I interferons in infections and macrophage activation by IF

  • Conrad E, Resch TK, Gogesch P, Kalinke U, Bechmann I, Bogdan C, Waibler Z. Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice. Hepatology. 2014 Apr;59(4):1555-63.
  • Bussmeyer, U., Sarkar, A., Broszat, K., Lüdemann, T., Möller, S., van Zandberger, G., Bogdan, Ch., Behnen-Haerer, M., Dumler, J.S., von Loewenich, F.D., Solbach, W., Laskay, T.: Impairment of interferon-γ signaling in human neutrophils infected with Anaplasma phagocytophilum. (2010) Infect. Immun. 78 : 358 – 363
  • Schleicher U and Bogdan C. Generation, Culture and Flow-Cytometric Characterization of Primary Mouse Macrophages. 2009. Methods Mol Biol. 531:203-24.
  • Fejer, G., L. Drechsel, J. Liese, U. Schleicher, Z. Ruzsics, N. Imelli, U.F. Greber, S. Keck, B. Hildenbrand, A. Krug, C. Bogdan, and M.A. Freudenberg. 2008. Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog 4:e1000208.
  • Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J.A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204:893-906.
  • Bogdan, C., and U. Schleicher. 2006. Production of interferon-gamma by myeloid cells--fact or fancy? Trends Immunol 27:282-290.
  • Schleicher, U., A. Hesse, and C. Bogdan. 2005. Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-gamma in IL-12/IL-18-stimulated mouse macrophage populations. Blood 105:1319-1328.
  • Bogdan, C., J. Mattner, and U. Schleicher. 2004. The role of type I interferons in non-viral infections. Immunol Rev 202:33-48.
  • Mattner, J., A. Wandersee-Steinhäuser, A. Pahl, M. Röllinghoff, G.R. Majeau, P.S. Hochman, and C. Bogdan. 2004. Protection against progressive leishmaniasis by IFN-b. J. Immunol. 172:7574-7582.
  • Frucht, D.M., T. Fukao, C. Bogdan, H. Schindler, J.J. O´Shea, and S. Koyasu. 2001. Interferon-g production by antigen presenting cells: mechanisms emerge. Trends Immunol. 22:556-560.
  • Schindler, H., M.B. Lutz, M. Röllinghoff, and C. Bogdan. 2001. The production of IFN-g by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J. Immunol. 166:3075-3082.
  • Bogdan, C. 2000. The function of type I interferons in antimicrobial immunity. Curr. Opin. Immunol. 12:419-424.
  • Diefenbach, A., H. Schindler, N. Donhauser, E. Lorenz, T. Laskay, J. MacMicking, M. Röllinghoff, I. Gresser, and C. Bogdan. 1998. Type 1 interferon (IFN-a/b) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8:77-87.

Clinics and epidemiology of leishmaniasis

  • Bode SF, Bogdan C, Beutel K, Behnisch W, Greiner J, Henning S, Jorch N, Jankofsky M, Jakob M, Schmid I, Veelken N, Vraetz T, Janka G, Ehl S, Lehmberg K. Hemophagocytic lymphohistiocytosis in imported pediatric visceral leishmaniasis in a nonendemic area. Pediatr. 2014 Jul;165(1):147-153.e1.
  • Haeberlein S, Fischer D, Thomas SM, Schleicher U, Beierkuhnlein C, Bogdan C. First assessment for the presence of phlebotomine vectors in Bavaria, Southern Germany, by combined distribution modeling and field surveys. PLoS One. 2013 Nov 18;8(11):e81088.
  • Eichner S, Thoma-Uszynski S, Herrgott I, Sebald H, Debus A, Tsianakas A, Ehrchen J, Harms G, Simon M, Sunderkötter C, Bogdan C. Clinical complexity of Leishmania (Viannia) braziliensis infections amongst travelers. Eur J Dermatol. 2013 Apr 1;23(2):218-23. doi: 10.1684/ejd.2013.1934.
  • Bogdan, C. 2012a. Leishmaniasis in rheumatology, haematology and oncology: epidemiological, immunological and clinical aspects and caveats. Annals of the rheumatic diseases 71 Suppl 2:i60-66.
  • Amann, K., C. Bogdan, T. Harrer, and J. Rech. 2012. Renal leishmaniasis as unusual cause of nephrotic syndrome in an HIV patient. Journal of the American Society of Nephrology : JASN 23:586-590.
  • von Stebut, E., U. Schleicher, and C. Bogdan. 2012. [Cutaneous leishmaniasis as travelers' disease. Clinical presentation, diagnostics and therapy]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 63:233-246; quiz 247-238.
  • Bogdan, C., Schönian, G., Banuls, A.-L., Hide, M., Pratlong, F., Lorenz, E., et al (2001) Visceral leishmaniosis in a German child that had never entered a known endemic area: case report and review of the literature. Clin. Infect. Dis. 32: 302-307.
  • Bogdan C. 2002. Reisemedizinisch relevante Protozoenerkrankungen im Kindesalter: Leishmaniose und Malaria als Beispiele. Kinder- und Jugendmedizin 2: 73-83
  • Bogdan C. 2006. Leishmaniosen im Kindesalter. Monatsschrift Kinderheilkunde 154: 221-228
  • Bogdan C., Reiter-Iwona I. 2009. Leishmaniosen. In: MIQ – Qualitätsstandards in der Mikrobiologischen Diagnostik, Heft 4 Parasitosen (Janitschke et al.) (im Druck)
  • Gothe, R. (1991) Leishmaniosen des Hundes in Deutschland: Erregerfauna und -biologie, Epidemiologie, Klinik, Pathogenese, Diagnose, Therapie und Prophylaxe. Kleintierpraxis. 36: 69-84.
  • Köhler, K., Stechele, M., Hetzel, U., Domingo, M., Schönian, G., Zahner, H. and Burkhardt, E. (2002) Cutaneous leishmaniosis in a horse in southern Germany caused by Leishmania infantum. Vet. Parasitol. 109: 9-17.
  • Landmann E, Bogdan C, Donhauser N, Artlich A, Staude B, Gortner L: Leishmaniose mit kutaner und viszeraler Beteiligung bei einem 13 Jahre alten Jungen. Klinische Pädiatrie 212 (2000) 266-267
  • Naucke, T.J. and Pesson, B. (1999) Presence of Phlebotomus (Transphlebotomus) mascittii Grassi, 1908 (Diptera: Psychodidae) in Germany. Parasitol. Res. 86: 335-336.
  • Weitzel, T., Mühlberger, N., Jelinek, T., Schunk, M., Ehrhardt, S., Bogdan, C., et al (2004) Imported leishmaniasis in Germany 2001-2004: data of the SIMPID surveillance network. Eur. J. Clin. Microbiol. Infect. Dis. 24: 471-476.

Diagnostics and Therapy of leishmania

  • Jebran AF, Schleicher U, Steiner R, Wentker P, Mahfuz F, Stahl HC, Amin FM, Bogdan C, Stahl KW. Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul. PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2694
  • Anish C, Martin CE, Wahlbrink A, Bogdan C, Ntais P, Antoniou M, Seeberger PH. Immunogenicity and diagnostic potential of synthetic antigenic cell surface glycans of Leishmania. ACS Chem Biol. 2013 Nov 15;8(11):2412-22.
  • Butsch F, Faulde M, Debus A, Bogdan C, von Stebut E. Two cases of successful treatment of multilesional cutaneous leishmaniasis with liposomal amphotericin B. J Dtsch Dermatol Ges. 2013 Jan;11(1):83-5.
  • Boecken, G., Sunderkoetter, C., Bogdan, C., Weitzel, T., Fischer, M., Müller, A., Loebermann, M., Anders, G., von Stebut, E., Schunk, M., Burchard, G., Grobusch, M., Bialek, R., Harms-Zwingenberger, G., Fleischer, B., Pietras, M., Faulde, M., Erkens, K.: Diagnosis and therapy of cutaneous and mucocutaneous Leishmaniasis in Germany. 2011. J. Dtsch. Dermatol. Ges. 8 : 1 – 51.
  • Valdez CA, Saavedra JE, Showalter BM, Davies KM, Wilde TC, Citro ML, Barchi JJ Jr, Deschamps JR, Parrish D, El-Gayar S, Schleicher U, Bogdan C, Keefer LK. Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity. J Med Chem. 2008 Jul 10;51(13):3961-70. Epub 2008 Jun 6.
  • Miloš R. Filipović, Alaric C.W. Koh, Stéphane Arbault, Vesna Niketić, Andrea Debus, Ulrike Schleicher, Christian Bogdan, Manon Guille, Frederic Lemaitre, Christian Amatore, Ivana Ivanović-Burmazović. A new way to strike inflammation from both sides: Mn(II) pentaazamicrocyclic SOD mimics as nitric oxide dismutases. A single cell study. Angewandte Chemie (Internationale Edition) 2010 Jun 7;49(25):4228-32.

 

 

 

 
 
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Summary