Relevant Publications

Microbiology

Head of Institute:
Prof. Dr. med. Christian Bogdan

Relevant Publications

NK cells and TLR9 in leishmaniasis  

  • Chittappen, K.P., Häberlein, S., Sebald, H., Schleicher, U., Bogdan, Ch.: Leishmania-infected macrophages are target of NK cell-derived cytokines but not of NK cell cytotoxicity. 2011. Infect. Immun. 79 : 2699-2708.
  • Haeberlein S, Sebald H, Bogdan C, Schleicher U. 2010. IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo. Eur J Immunol 40(6):1708-1717.
  • Liese, J., U. Schleicher, and C. Bogdan. 2008. The innate immune response against Leishmania parasites. Immunobiology 213:377-387.
  • Liese, J., U. Schleicher, and C. Bogdan. 2007. TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. Eur J Immunol 37:3424-3434.
  • Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J.A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204:893-906.
  • Schleicher, U., J. Mattner, M. Blos, H. Schindler, M. Rollinghoff, M. Karaghiosoff, M. Muller, G. Werner-Felmayer, and C. Bogdan. 2004. Control of Leishmania major in the absence of Tyk2 kinase. Eur J Immunol 34:519-529.

Inducible NO synthase, arginase and reactive oxygen intermediates

  • Mahnke A, Meier RJ, Schatz V, Hofmann J, Castiglione K, Schleicher U, Wolfbeis OS, Bogdan C, Jantsch J. Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages. J Invest Dermatol. 2014 Feb 28. doi: 10.1038/jid.2014.121.
  • Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G. Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection. J Exp Med. 2013 May 6;210(5):855-73.
  • Fritzsche, C., U. Schleicher, and C. Bogdan. 2010. Endothelial NO synthase limits the inflammatory response in mouse cutaneous leishmaniasis. Immunobiology 215:826-832.
  • König T, Bogdan C, Schleicher U. Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2alpha. Immunobiology. 2009;214(9-10):822-7.
  • El Kasmi, K.C., J.E. Qualls, J.T. Pesce, A.M. Smith, R.W. Thompson, M. Henao-Tamayo, R.J. Basaraba, T. Konig, U. Schleicher, M.S. Koo, G. Kaplan, K.A. Fitzgerald, E.I. Tuomanen, I.M. Orme, T.D. Kanneganti, C. Bogdan, T.A. Wynn, and P.J. Murray. 2008. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol 9:1399-1406.
  • Valdez, C.A., J.E. Saavedra, B.M. Showalter, K.M. Davies, T.C. Wilde, M.L. Citro, J.J. Barchi, Jr., J.R. Deschamps, D. Parrish, S. El-Gayar, U. Schleicher, C. Bogdan, and L.K. Keefer. 2008. Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity. J Med Chem 51:3961-3970.
  • Rocha, F.J., U. Schleicher, J. Mattner, G. Alber, and C. Bogdan. 2007. Cytokines, Signaling Pathways, and Effector Molecules Required for the Control of Leishmania (Viannia) braziliensis in Mice. Infect Immun 75:3823-3832.
  • Blos, M., U. Schleicher, F.J. Soares Rocha, U. Meissner, M. Rollinghoff, and C. Bogdan. 2003. Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase. Eur J Immunol 33:1224-1234.

Type I interferons in infections and macrophage activation by IFN-γ

  • Desel C., Werninghaus K., Ritter M., Jozefowski K., Wenzel J., Russkamp N., Schleicher U., Christensen D., Wirtz S., Kirschning C., Agger E.M., Prazeres da Costa C. and Lang R. 2013. The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling. PLoS One 8:e53531.
  • Schleicher U and Bogdan C. Generation, Culture and Flow-Cytometric Characterization of Primary Mouse Macrophages. 2009. Methods Mol Biol. 531:203-24.
  • Fejer, G., L. Drechsel, J. Liese, U. Schleicher, Z. Ruzsics, N. Imelli, U.F. Greber, S. Keck, B. Hildenbrand, A. Krug, C. Bogdan, and M.A. Freudenberg. 2008. Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog 4:e1000208.
  • Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J.A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204:893-906.
  • Bogdan, C., and U. Schleicher. 2006. Production of interferon-gamma by myeloid cells--fact or fancy? Trends Immunol 27:282-290.
  • Schleicher, U., A. Hesse, and C. Bogdan. 2005. Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-gamma in IL-12/IL-18-stimulated mouse macrophage populations. Blood 105:1319-1328.
  • Bogdan, C., J. Mattner, and U. Schleicher. 2004. The role of type I interferons in non-viral infections. Immunol Rev 202:33-48.

 Clinics and epidemiology of leishmaniasis

  • Wege A.K., Florian C., Ernst W., Zimara N., Schleicher U., Hanses F., Schmid M. and Ritter U. 2012. Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response. PLoS Negl Trop Dis 6:e1741.
  • Haeberlein S, Fischer D, Thomas SM, Schleicher U, Beierkuhnlein C, Bogdan C. First assessment for the presence of phlebotomine vectors in Bavaria, Southern Germany, by combined distribution modeling and field surveys. PLoS One. 2013 Nov 18;8(11):e81088.
  • von Stebut, E., U. Schleicher, and C. Bogdan. 2012. [Cutaneous leishmaniasis as travelers' disease. Clinical presentation, diagnostics and therapy]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 63:233-246; quiz 247-238.

Diagnostics and Therapy of leishmaniasis

  • Jebran AF, Schleicher U, Steiner R, Wentker P, Mahfuz F, Stahl HC, Amin FM, Bogdan C, Stahl KW. Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul. PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2694
  • Valdez CA, Saavedra JE, Showalter BM, Davies KM, Wilde TC, Citro ML, Barchi JJ Jr, Deschamps JR, Parrish D, El-Gayar S, Schleicher U, Bogdan C, Keefer LK. Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity. J Med Chem. 2008 Jul 10;51(13):3961-70. Epub 2008 Jun 6.
  • Miloš R. Filipović, Alaric C.W. Koh, Stéphane Arbault, Vesna Niketić, Andrea Debus, Ulrike Schleicher, Christian Bogdan, Manon Guille, Frederic Lemaitre, Christian Amatore, Ivana Ivanović-Burmazović. A new way to strike inflammation from both sides: Mn(II) pentaazamicrocyclic SOD mimics as nitric oxide dismutases. A single cell study. Angewandte Chemie (Internationale Edition) 2010 Jun 7;49(25):4228-32.
 
 
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